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However, lysine modification often yields heterogeneous products due to multiple reactive surface lysine residues in the antibody

On the other hand, a recent review reported that the quality of the regenerated tissue varies according to the clinical trial

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The ROS-mediated damage is further enhanced in older individuals since during aging, GSH levels appear to diminish in numerous tissues, thereby placing cells at increased risk of stress-related death (Maher, 2005)